Yazar "Koprulu, Tugba Kul" için listeleme
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Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents
Koprulu, Tugba Kul; Okten, Salih; Tekin, Saban; Cakmak, Osman (Wiley, 2019)Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted ... -
Detection of mechanism and anticancer activity of the new quinoline compounds MC20 and MC21
Koprulu, Tugba Kul; Tekin, Saban; Okten, Salih; Cinar, Merve; Duman, Seda; Cakmak, Osman (Elsevier Science Bv, 2014)… -
In vitro antiproliferative/cytotoxic activity of 2,3 '-biindole against various cancer cell lines
Okten, Salih; Erenler, Ramazan; Koprulu, Tugba Kul; Tekin, Saban (Tubitak Scientific & Technical Research Council Turkey, 2015)2,3'-Biindole (2) was synthesized via bromination of indole (1) with molecular bromine and underwent simultaneous dimerization. Antiproliferative and cytotoxic activity of 2 was investigated in vitro on C6 (rat brain tumor), ... -
A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents
Okten, Salih; Cakmak, Osman; Tekin, Saban; Koprulu, Tugba Kul (Bentham Science Publ Ltd, 2017)Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, ...